The major components of LunaGel™ include the ECM proteins collagen type I, III, IV, and V, as well as connective tissue glycoproteins and proteoglycans. LunaGel™ retains the intrinsic cell-instructive bioactivity of natural ECMs facilitating cell attachment, proliferation, differentiation, migration, and proteolytic degradation. LunaGel™’s unique photocrosslinking technology allows unprecedented control over matrix porosity and stiffness, allowing researchers to replicate the physicochemical properties of a variety of healthy and diseased tissues in 3D cell culture applications.

 

LunaGel™ ECM has been successfully used in a wide range of applications including cell attachment and proliferation, stem cell culture and differentiation, mechanotransduction assays, cancer spheroid assays, angiogenesis assays, 3D bioprinting, tissue engineering, and more.

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LunaGel™ is supplied as a sterile solution with freeze-dried photoinitiator. Available as Low Stiffness (0 - 6.5 kPa) and High Stiffness kit (0 - 25 kPa). Reconstitute the photoinitiator in PBS, mix with LunaGel™ ECM and cells, and photocrosslink the solution using the  Luna Crosslinker™ to form 3D cell culture models. By controlling the duration of light exposure you can produce hydrogels with a specified stiffness. Add your favourite culture media and you're culturing in 3D!

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How it works

 

Create physiological cell culture models in 15 min