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LunaGel™ - Hyaluronic Acid

LunaGel™ - Hyaluronic acid (HA) is photocrosslinkable extracellular matrix based on high molecular weight HA, a linear polysaccharide consisting of alternating D-glucuronic acid and N-acetyl-D-glucosamine units found in connective tissues. LunaGel™ - HA has applications as a matrix for 3D cell culture, tissue engineering, 3D bioprinting, and drug delivery. 

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Product Info

The major components of LunaGel™ include the ECM proteins collagen type I, III, IV, and V, as well as connective tissue glycoproteins and proteoglycans. LunaGel™ retains the intrinsic cell-instructive bioactivity of natural ECMs facilitating cell attachment, proliferation, differentiation, migration, and proteolytic degradation. LunaGel™’s unique photocrosslinking technology allows unprecedented control over matrix porosity and stiffness, allowing researchers to replicate the physicochemical properties of a variety of healthy and diseased tissues in 3D cell culture applications.


LunaGel™ ECM has been successfully used in a wide range of applications including cell attachment and proliferation, stem cell culture and differentiation, mechanotransduction assays, cancer spheroid assays, angiogenesis assays, 3D bioprinting, tissue engineering, and more.

LunaGel™ is supplied as a sterile solution with freeze-dried photoinitiator. Available as Low Stiffness (0 - 6.5 kPa) and High Stiffness kit (0 - 25 kPa).

Reconstitute the photoinitiator in PBS, mix with LunaGel™ ECM and cells, and photocrosslink the solution using the  Luna Crosslinker™ to form 3D cell culture models. By controlling the duration of light exposure you can produce hydrogels with a specified stiffness. Add your favourite culture media and you're culturing in 3D!

How it works
Create physiological cell culture models in 15 min

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This kit contains enough LunaGel™ to create a total volume of 10 mL hydrogel.


  • 5 mL LunaGel™ ECM (2x solution, sterile)

  • 5 vials of photoinitiator (freeze-dried, sterile)

  • Low stiffness (0 - 6.5 kPa), 10ml

  • High stiffness (0 - 25 kPa), 7.5ml


  • Liquid at temperatures over 4 °C. No heating or cooling required.

  • Photocrosslinking technology allows highly controlled mechanical properties.

  • High Bioactivity (cell attachment, proteolytic degradation).

  • Compatible with automated liquid handling.

3D cell culture has never been easier
Check out some examples of LunaGel in action

Prepare 3D models in a matter of minutes

See the LunaGel™ video protocol below 
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